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And Chasseauld, L. F. (1969). The role of glutathione and glutathione S-transferases in mercapturic acid biosynthesis. Adv. Enzymol. 32, 173-219. Kriek, E. (1965). On the interaction of N-2-fluorenylhydroxylamine with nucleic acids in vitro. Biochem. Biophys. Res. Commun. 20, 793-799. Miller, E. , and Miller, J. A. (1966). Nucleic acid guanine: Reaction with the carcinogen N-acetoxy-2-acetylaminofluorene. Science 153, 1125-1127. Miller, E. C. (1978). Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.

250, 8510-8517. 49. , and Tada, M. (1976). Metabolic activation of 4-nitroquinoline TV-oxide and its binding to nucleic acid. In "Fundamentals of Cancer Prevention" (P. N. Magee, S. , Sugimura, and T. ), pp. 217-227. Univ. Park Press, Baltimore, Maryland. 26 Scott W. Cummings and Russell A. Prough 50. , and Oshina, T. (1970). Characteristics of nitro reduction of the carcinogenic agent, 4-nitroquinolone-N-oxide. Biochem. Pharmacol. 19, 45-55. 51. Mason, R. , and Holtzman, J. L. (1975). The role of catalytic Superoxide formation in the 0 2 inhibition of nitroreductase.

Purification of liver microsomal cytochrome P-448 from 3-methylcholanthrene-treated rabbits. Mol. Pharmacol. 11, 874-878. 1. Metabolic Formation of Toxic Metabolites 25 33. , and Sato, R. (1974). A gel-electrophoretically homogeneous preparation of cytochrome P-450 from liver microsomes of phenobarbital pre treated rabbits. Biochem. Biophys. Res. Commun. 60, 8-14. 34. Strobel, H. , Lu, A. Y. , and Coon, M. J. (1970). Phosphatidylcholine requirements in the enzymatic reduction of hemoprotein P-450 and in fatty acid, hydrocarbon, and drug hydroxylation.

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