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16. The relation between the response (the percentage of individuals investigated who have reacted with a certain effect) and the dose of the xenobiotic (linear scale). This is a cumulative representation of the number of reacting individuals as presented in Fig. 15. A similar relation is also found in the case of a log normal distribution with the dose on a log scale (lower scale). A log normal distribution is exhibited in Figs. 17 and 18. In the figure, the values of a that characterize the slope of the curve, and therefore the dispersion of the values around the E D 5, 0are also given.

Although exceptional, the products of oxidative conversion of xenobiotics may sometimes be conjugated with the formation of chemically reactive and biologically alkylating sulfates with a carcinogenic and mutagenic action. Also, the glutathione transferase system has a protective function against these agents. , aniline), namely, the hydroxylamines, are not only involved in biological alkylation processes but can also serve in a redox system which causes the oxidation of hemoglobin to methemoglobin.

3 and 4) but also the inherent risks outlined above. Protecting systems have also developed that scavenge the toxic biologically alkylating reactive intermediates often inevitably generated by biochemical conversion of xenobiotics. These systems predominantly occur in the liver. 1. The glutathione transferase system, which takes care of neutralization of the chemically reactive intermediates by coupling with glutathione, which implies the formation of usually nonreactive conjugation products that appear in the urine as water-soluble mercapturic acid derivatives.

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