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C M M In cid en ce/100K W o rld Po p u latio n Figure 4 shows the CMM incidences in the years 1980 and 2000 for Australia by latitude. The CMM incidence decreases with increasing latitude until ~35°S where it appears to increase somewhat with increasing latitude in 2000. 60 1980 50 2000 40 30 20 10 0 10 20 30 40 50 Latitude (°S) Fig. 4. The CMM incidences in the years 1980 and 2000 for Australia by latitude. Figure 5A shows an exponential increasing incidence of CMM with latitude in the southern hemisphere.

2009), melanoma incidence has been increasing steadily over the last several decades (Erickson and Driscoll, 2010). According to the World Health Organization, approximately 20,000 people worldwide die from melanoma each year. One of the most striking clinical aspects of melanoma is the profound difference in incidence between persons of fair and dark skin complexions (Garbe and Leiter, 2009). Deposition of UV-blocking melanin pigment in the epidermis accounts for much of the protection realized by persons of dark skin complexion, however risk for melanoma does not simply correlate with amount of melanin in the skin.

Science 1982;216:1001-1003. Moehrle M, Soballa M, Korn M. UV exposure in cars. Photodermatol Photoimmunol Photomed 2003;19:175-181. , eds (1987) Cancer Incidence in Five Continents, Vol. V IARC Scientific Publications No. 88, Lyon, IARC Newton-Bishop JA, Chang YM, Elliott F, Chan M, Leake S, Karpavicius B, Haynes S, Fitzgibbon E, Kukalizch K, Randerson-Moor J, Elder DE, Bishop DT, Barrett JH. 2011. Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate.

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