Download Acute Renal Failure: Pathophysiology, Prevention, and by Vittorio E. Andreucci (auth.), Vittorio E. Andreucci (eds.) PDF

By Vittorio E. Andreucci (auth.), Vittorio E. Andreucci (eds.)

`No doubt than it good merits its position within the library of the younger and no more younger nephrologists either customarily within the medical perform or in research.'
Nephron (1986)
`The e-book is an updated and worthy compendium of present wisdom within the scientific administration of acute renal failure.'
Journal of the Royal Society of drugs, seventy eight (1985)

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Extra info for Acute Renal Failure: Pathophysiology, Prevention, and Treatment

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Infusion of 1. PATHOPHYSIOLOGY OF ACUTE RENAL FAILURE PGE 2 {156, 181} may be due to a "normalization" of that proportion {183}. It has also been suggested that the protective effect of saline against this model of ARF is PGEz-mediated since it is blunted by indomethacin and restored by PGE 2 administration {156}. There are, indeed, some experimental data demonstrating that saline infusion induces release of PGs {185}; this may be the mechanism by which saline loading elicits partial protection on the initial "functional" stage of this model of ARF.

Thus, dogs with hemorrhagic hypotension exhibited reduced RBF and GFR, especially when PGs were inhibited by pretreatment with indomethacin; unilateral intrarenal infusion of a specific All antagonist could attenuate the impairment of renal perfusion and function, but only when renal denervation was also associated was a 31 great protection of RBF and GFR observed [261, 262]. ) [205]. But no appreciable effect on TGF response was observed during alpha blockade with phenoxybenzamine or phentolamine, nor following chemical renal denervation with 6-hydroxydopamine (which is known to destroy adrenergic nerve terminals), nor following depletion of adrenergic nerve vescicles with reserpine [205].

ARACHIDONIC ACID -------1> (Cyclooxigenase) j PGG2 PGH2 (S (S /) I ~ (Ureteral obstruction. ' ... s- lit..... PGE2 (9-ketoreductase). PGF2C1. ~ / / / /,11 / / t TxA2 ( THROMBOXANE ) ) (Kinins. Salt intake) " ( Indomethacin. Furosemide. Ethacrinic acid) " " (15 hydroxy PG dehydrogenase) ''6 DEGRADATION PRODUCTS + - - Stimulation <)---- Inhibition FIGURE 1-1. Synthesis and degradation of prostaglandins. It is now well established, instead, that PG synthesis, within the kidney, occurs both in the cortex (mainly PGI 2 ) and in the medulla (mainly PGE 2 ) [269J.

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